Publications

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Journal Article
Llaneras F, Picó J.  2010.  Which metabolic pathways generate and characterize the flux space? A comparison among elementary modes, extreme pathways and minimal generators. Journal of Biomedicine and Biotechnology. 2010:753904.
Tortajada M, Llaneras F, Picó J.  2010.  Validation of a constraint-based model of Pichia pastoris metabolism under data scarcity.. BMC Systems Biology. 4:115.
Bosque G, Folch-Fortuny A, Picó J, Ferrer A, Elena S.F.  2014.  Topology analysis and visualization of Potyvirus protein-protein interaction network. BMC Systems Biology. 8(1)
Nuñez S, De Battista H, Garelli F, Picó J.  2014.  Sufficient conditions for state observability in multi-substrate bioprocesses with additive growth dynamics. IEEE Latin America Transactions. 12(5)
Llaneras F, Picó J.  2008.  Stoichiometric modelling of cell metabolism.. Journal of bioscience and bioengineering. 105:1–11.
Picó J, Picó–Marco E, Vignoni A, De Battista H.  2013.  Stability preserving maps for finite-time convergence: super-twisting sliding-mode algorithm. Automatica. 49(2):539.
De Battista H, Picó J, Garelli F, Vignoni A.  2011.  Specific growth rate estimation in (fed-)batch bioreactors using second-order sliding observers. Journal of Process Control. 21:1049–1055.
Picó J, De Battista H, Garelli F.  2009.  Smooth sliding-mode observers for specific growth rate and substrate from biomass measurement. Journal of Process Control.
Picó-Marco E, Picó J, De Battista H.  2005.  Sliding mode scheme for adaptive specific growth rate control in biotechnological fed-batch processes. International Journal of Control. 78:128–141.
Camacho J, Picó J, Ferrer A.  2007.  Self-tuning run to run optimization of fed-batch processes using unfold-PLS. AIChE journal.
Nuñez S, De Battista H, Garelli F, Vignoni A, Picó J.  2013.  Second-Order Sliding Mode Observer for Multiple Kinetic Rates Estimation in Bioprocesses. Control Engineering Practice. 21(9):1259-1265.
Revert A, Garelli F, Picó J, De Battista H, Rossetti P, Vehi J, Bondia J.  2013.  Safety Auxiliary Feedback Element for the Artificial Pancreas in Type 1 Diabetes. IEEE Trans. on Biomedical Engineering. 60(8):2113-2122.
De Battista H, Picó J, Garelli F, Navarro J.  2012.  Reaction rate reconstruction from biomass concentration measurement in bioreactors using modified second-order sliding mode algorithms. Bioprocess and Biosystems Engineering. :1-11.
Llaneras F, Picó J.  2007.  A procedure for the estimation over time of metabolic fluxes in scenarios where measurements are uncertain and/or insufficient. BMC bioinformatics.
Llaneras F, Sala A., Picó J.  2009.  A possibilistic framework for constraint-based metabolic flux analysis. BMC Systems Biology. 3
Reynoso-Meza G, Carrillo-Ahumada J, Boada Y, Picó J.  2016.  PID controller tuning for unstable processes using a multi-objective optimisation design procedure. IFAC-PapersOnLine . 49(7):289.
Boada Y, Vignoni A, Reynoso-Meza G, Picó J.  2016.  Parameter identification in synthetic biological circuits using multi-objective optimization. IFAC-PapersOnLine. 49(26):82.
Boada Y, Pitarch JL, Vignoni A, Reynoso-Meza G, Picó J.  2016.  Optimization Alternatives for Robust Model-based Design of Synthetic Biological Circuits. FAC-PapersOnLine . 49(7):826.
De Battista H, Picó J, Picó-Marco E.  2012.  Nonlinear PI control of fed-batch processes for growth rate regulation. Journal of Process Control. 22:789-797.
Camacho J, Picó J.  2006.  Multi-phase principal component analysis for batch processes modelling. Chemometrics and intelligent laboratory systems.
Camacho J, Picó J, Ferrer A.  2008.  Multi-phase analysis framework for handling batch process data. Journal of Chemometrics. 22:632–643.
Folch-Fortuny A, Tortajada M, Prats-Montalbán JM, Llaneras F, Picó J, Ferrer A.  2015.  MCR-ALS on metabolic networks: Obtaining more meaningful pathways. Chemometrics and Intelligent Laboratory Systems. 142:293-303.
Picó J, Sanchez A, Bondia J, Escudero D, Torregrosa A, Correcher C.  2005.  Intelligent Robotic Cell for Trencad&\#205;s Mosaics Manufacturing}. IEEE Transactions on Systems, Man and Cybernetics, Part C (Applications and Reviews). 35:75–86.
De Battista H, Picó J, Picó-Marco E.  2006.  Globally stabilizing control of fed-batch processes with Haldane kinetics using growth rate estimation feedback. Journal of Process Control. 16:865–875.
De Battista H, Jamilis M, Garelli F, Picó J.  2017.  Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws. Automatica.

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