Cancer treatments have serious well-known side effects on patients due to the systemic action of the drugs involved.
Synthetic biology aims to program living microorganisms with genetic circuits that are becoming powerful tools in various fields, including oncology. Bacteria – often considered pathogenic agents-, have been used as cancer treatments since the early 20th century. Advances in genetic engineering, synthetic biology, microbiology, and oncology have improved bacterial therapies, making them safer and more effective.
We are working on Synthetic biology-based bacterial cancer therapies to personalize patient’s treatments that provides early antitumoral action while minimizing damage to healthy tissues and ensuring safety for the environment and the patient. Personalization means “a systematic modular design for bacterial cancer therapy alongside all the requirements that any microorganism should reach before to be considered as an effective bacterial cancer therapy”.